國家衛生研究院 NHRI:Item 3990099045/13791
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    题名: Multi-omics reveals the immunological role and prognostic potential of mitochondrial ubiquitin ligase march5 in human breast cancer
    作者: Chu, PY;Tzeng, YDT;Chiu, YH;Lin, HY;Kuo, CH;Hou, MF;Li, CJ
    贡献者: National Institute of Cancer Research
    摘要: E3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human MARCH5 gene. The main objective of this study was to visualize the prognosis of MARCH5 in breast cancer and to determine the relationship between MARCH5 expression and tumor immunity. MARCH5 expression was significantly higher in several cancers, including breast cancer (BRCA), compared with corresponding normal tissues. Not only was high MARCH5 expression associated with poorer overall survival, but also MARCH5 expression was positively correlated with the number of tumor-infiltrating immune cells in BRCA malignant tissues. Furthermore, MARCH5 expression showed a strong correlation with various immune markers of BRCA, suggesting its role in regulating tumor immunity. MARCH5 is a useful prognostic biomarker in several cancers, and its expression is highly correlated with tumor immune cell infiltration, and increased MARCH5 expression may serve as a new biomarker for BRCA diagnosis and prognosis.
    日期: 2021-09-26
    關聯: Biomedicines. 2021 Sep 26;9(10):Article number 1329.
    Link to: http://dx.doi.org/10.3390/biomedicines9101329
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2227-9059&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000711468000001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116045871
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