國家衛生研究院 NHRI:Item 3990099045/13802
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    题名: Lipid-assisted synthesis of magnesium-loaded hydroxyapatite as a potential bone healing material
    作者: Chen, YH;Yu, YS;Yu, PT;Fang, HW;Chang, YC;Wu, KCW
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Background: Magnesium-loaded hydroxyapatite (Mg@HAp) is a potential biomaterial for bone healing application but has not been comprehensively synthesized yet. Methods: In this study, we utilize phosphatidylcholine (PC)-assisted method for synthesizing Mg@HAp with controllable Mg amount from 1.44 to 10.64 wt%. It is proposed that the negatively charged phosphate functional group of PC could act on cations (i.e. Mg2+ or Ca2+), which provides stable nucleation for the formation of Mg@HAp. Significant findings: By optimizing the synthesis conditions, we successfully prepared a Mg@HAp with a relatively low crystallinity which is similar to human bone structure, as evidenced by XRD measurement. The in vitro test of bone cells (MG-63) shows that the release of Mg2+ ions from Mg@HAp enhances cellular proliferation and differentiation. We believe the synthesized Mg@HAp would be a promising biomaterial in orthopedic applications.
    日期: 2021-12
    關聯: Journal of the Taiwan Institute of Chemical Engineers. 2021 Dec;129:40-51.
    Link to: http://dx.doi.org/10.1016/j.jtice.2021.09.019
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1876-1070&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000730177100004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85115916612
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