國家衛生研究院 NHRI:Item 3990099045/13807
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    題名: Is pathological T4a an independent indication of adjuvant therapy in buccal mucosal or gingival squamous cell carcinoma?
    作者: Chao, TY;Chan, LP;Lee, HH;Kao, YH;Jhong, YP;Chiang, CH;Chuang, ST;Huang, CJ
    貢獻者: NHRI Graduate Student Program
    摘要: Background: To evaluate the clinicopathologic factors affecting the clinical outcomes in pathological T4aN0 (pT4aN0) buccal mucosal or gingival squamous cell carcinoma (SCC). Methods: This was a retrospective study of 113 consecutive patients with diagnoses of pT4aN0 buccal mucosal or gingival SCC between January 2010 and November 2018. The median follow-up was 38 months (range, 1–119 months). Kaplan-Meier and Cox proportional-hazards models were used for survival analysis. Results: In the entire study, 5-year overall survival (OS) and disease-free survival (DFS) rates were 73.7% and 83.6%, respectively. Univariate analysis revealed that lymphovascular invasion (LVI), perineural invasion (PNI), and margin status had significant effects on the DFS rate, and tumor cell differentiation had a significant effect on OS rate. Multivariate Cox regression analysis revealed margin status was the only significant factor affecting DFS. The patients (n=38) without the inadequate margin, LVI, PNI, and poorly differentiated tumor cells had a better 5-year DFS rate (P=0.023) whether they had received adjuvant treatment or not (91.5% versus 100%). However, no significant effect on the OS rate was found (P=0.544). Conclusions: The patients who had no adverse pathologic factors exhibited fair DFS rate without adjuvant therapy. The adjuvant therapy may not be considered for this subgroup.
    日期: 2021-09-30
    關聯: Therapeutic Radiology and Oncology. 2021 Sep 30;5(3):Article number 6920.
    Link to: http://dx.doi.org/10.21037/TRO-21-1
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85115983306
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