國家衛生研究院 NHRI:Item 3990099045/13817
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    题名: miRNA as a modulator of immunotherapy and immune response in melanoma
    作者: Nguyen, MHT;Luo, YH;Li, AL;Tsai, JC;Wu, KL;Chung, PJ;Ma, N
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Immune checkpoint inhibitors are a promising therapy for the treatment of cancers, includ-ing melanoma, that improved benefit clinical outcomes. However, a subset of melanoma patients do not respond or acquire resistance to immunotherapy, which limits their clinical applicability. Recent studies have explored the reasons related to the resistance of melanoma to immune checkpoint inhibitors. Of note, miRNAs are the regulators of not only cancer progression but also of the response between cancer cells and immune cells. Investigation of miRNA functions within the tumor microen-vironment have suggested that miRNAs could be considered as key partners in immunotherapy. Here, we reviewed the known mechanism by which melanoma induces resistance to immunotherapy and the role of miRNAs in immune responses and the microenvironment.
    日期: 2021-11-08
    關聯: Biomolecules. 2021 Nov 8;11(11):Article number 1648.
    Link to: http://dx.doi.org/10.3390/biom11111648
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2218-273X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000729291600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85118476915
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