國家衛生研究院 NHRI:Item 3990099045/13821
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    题名: Type-3 hyaluronan synthase attenuates tumor cells invasion in human mammary parenchymal tissues
    作者: Lee, WJ;Tu, SH;Cheng, TC;Lin, JH;Sheu, MT;Kuo, CC;Changou, CA;Wu, CH;Chang, HW;Chang, HL;Chen, LC;Ho, YS
    贡献者: NHRI Graduate Student Program;Institute of Biotechnology and Pharmaceutical Research
    摘要: The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular matrix can attenuate the invasion of human breast tumor cells. Decreased HA levels in subcutaneous Has3-KO mouse tissues promoted orthotopic breast cancer (E0771) cell-derived allograft tumor growth. MDA-MB-231 cells premixed with higher concentration HA attenuate tumor growth in xenografted nude mice. Human patient-derived xenotransplantation (PDX) experiments found that HA selected the highly migratory breast cancer cells with CD44 expression accumulated in the tumor/stroma junc-tion. In conclusion, HAS3 and HA were detected in the stroma breast tissues at a high level attenuates effects for induced breast cancer cell death, and inhibit the cancer cells invasion at the initial stage. However, the highly migratory cancer cells were resistant to the HA-mediated effects with unknown mechanisms.
    日期: 2021-10-29
    關聯: Molecules. 2021 Oct 29;26(21):Article number 6548.
    Link to: http://dx.doi.org/10.3390/molecules26216548
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-3049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000728024100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85118405614
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