國家衛生研究院 NHRI:Item 3990099045/13838
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13838


    Title: Early-onset type 2 diabetes <60 years and risk of vascular complications
    Authors: Yen, FS;Lo, YR;Hwu, CM;Hsu, CC
    Contributors: Institute of Population Health Sciences
    Abstract: Aim: To compare long-term outcomes among three groups with different ages of diabetes onset. Method: 66,520 paired age-, and sex-matched persons with and without type 2 diabetes were selected from the Taiwan National Health Insurance Research Database from 2000 to 2012. Cox proportional hazards models were used to compare the outcomes. Using late-onset diabetes as a reference, adjusted difference in differences analyses were performed to assess excessive odds comparing diabetes versus non-diabetes for young-onset diabetes (YOD) and early-onset diabetes in the risks of mortality and vascular complications. Results: Persons with type 2 diabetes, irrespective of the onset age, had higher associated risks of all-cause mortality and vascular complications than their matched counterparts without diabetes. Compared to the odds of complications between those with diabetes and non-diabetes in the late-onset diabetes group, the excess odds in YOD are generally greater than in the early-onset diabetes (for stroke: 1.90 vs. 1.32; heart failure: 2.03 vs. 1.58; myocardial infarction: 3.02 vs. 1.56; and microvascular complications: 3.52 vs. 3.01). Conclusions: Diabetes with different ages of onset may imply distinct long-term health outcomes. The persons with young-onset and early-onset diabetes seem to bear excess risk for mortality and vascular complications.
    Date: 2021-12
    Relation: Diabetes Research and Clinical Practice. 2021 Dec;182:Article number 109129.
    Link to: http://dx.doi.org/10.1016/j.diabres.2021.109129
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0168-8227&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000744245100016
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85119035610
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles

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