國家衛生研究院 NHRI:Item 3990099045/13884
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13884


    Title: Molecular pathogenesis and the possible role of mitochondrial heteroplasmy in thoracic aortic aneurysm
    Authors: Suslov, AV;Afanasyev, MA;Degtyarev, PA;Chumachenko, PV;Ekta, MB;Sukhorukov, VN;Khotina, VA;Yet, SF;Sobenin, IA;Postnov, AY
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Thoracic aortic aneurysm (TAA) is a life-threatening condition associated with high mortality, in which the aortic wall is deformed due to congenital or age-associated pathological changes. The mechanisms of TAA development remain to be studied in detail, and are the subject of active research. In this review, we describe the morphological changes of the aortic wall in TAA. We outline the genetic disorders associated with aortic enlargement and discuss the potential role of mitochondrial pathology, in particular mitochondrial DNA heteroplasmy, in the disease pathogenesis.
    Date: 2021-12-13
    Relation: Life. 2021 Dec 13;11(12):Article number 1395.
    Link to: http://dx.doi.org/10.3390/life11121395
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2075-1729&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000743835700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85122349091
    Appears in Collections:[Shaw-Fang Yet] Periodical Articles

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