國家衛生研究院 NHRI:Item 3990099045/13890
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    题名: Mitochondrial function and Parkinson’s disease: From the perspective of the electron transport chain
    作者: Li, JL;Lin, TY;Chen, PL;Guo, TN;Huang, SY;Chen, CH;Lin, CH;Chan, CC
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Parkinson’s disease (PD) is known as a mitochondrial disease. Some even regarded it specifically as a disorder of the complex I of the electron transport chain (ETC). The ETC is fundamental for mitochondrial energy production which is essential for neuronal health. In the past two decades, more than 20 PD-associated genes have been identified. Some are directly involved in mitochondrial functions, such as PRKN, PINK1, and DJ-1. While other PD-associate genes, such as LRRK2, SNCA, and GBA1, regulate lysosomal functions, lipid metabolism, or protein aggregation, some have been shown to indirectly affect the electron transport chain. The recent identification of CHCHD2 and UQCRC1 that are critical for functions of complex IV and complex III, respectively, provide direct evidence that PD is more than just a complex I disorder. Like UQCRC1 in preventing cytochrome c from release, functions of ETC proteins beyond oxidative phosphorylation might also contribute to the pathogenesis of PD.
    日期: 2021-12-09
    關聯: Frontiers in Molecular Neuroscience. 2021 Dec 9;14:Article number 797833.
    Link to: http://dx.doi.org/10.3389/fnmol.2021.797833
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1662-5099&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000738114400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85121625304
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