國家衛生研究院 NHRI:Item 3990099045/1396
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    题名: Isolation of multipotent cells from human term placenta
    作者: Yen, BL;Huang, HI;Chien, CC;Jui, HY;Ko, BS;Yao, M;Shun, CT;Yen, ML;Lee, MC;Chen, YC
    贡献者: Stem Cell Research Center
    摘要: Current sources of stem cells include embryonic stem cells (ESCs) and adult stem cells (ASCs). However, concerns exist with either source: ESCs, with their significant ethical considerations, tumorigenicity, and paucity of cell lines; and ASCs, which are possibly more limited in potential. Thus, the search continues for an ethically conducive, easily accessible, and high-yielding source of stem cells. We have isolated a population of multipotent cells from the human term placenta, a temporary organ with fetal contributions that is discarded postpartum. These placenta-derived multipotent cells (PDMCs) exhibit many markers common to mesenchymal stem cells-including CD105/endoglin/SH-2, SH-3, and SH-4-and they lack hematopoietic-, endothelial-, and trophoblastic-specific cell markers. In addition, PDMCs exhibit ESC surface markers of SSEA-4, TRA-1-61, and TRA-1-80. Adipogenic, osteogenic, and neurogenic differentiation were achieved after culturing under the appropriate conditions. PDMCs could provide an ethically uncontroversial and easily accessible source of multipotent cells for future experimental and clinical applications.
    关键词: Biotechnology & Applied Microbiology;Oncology;Cell Biology;Hematology
    日期: 2005-01
    關聯: Stem Cells. 2005 Jan;23(1):3-9.
    Link to: http://dx.doi.org/10.1634/stemcells.2004-0098
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1066-5099&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000226259400001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=19944426620
    显示于类别:[陳耀昌(2002-2004)] 期刊論文
    [顏伶汝] 期刊論文

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