國家衛生研究院 NHRI:Item 3990099045/14065
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    题名: Aptamerized silica/gold nanocapsules for stimulated release of doxorubicin through remote two-photon excitation
    作者: Tew, LS;Lee, TH;Lo, LW;Khung, YL;Chen, NT
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Precision-based drug delivery via remote triggering is fast becoming an attractive therapeutic design and is highly useful in complicated clinical situations that may require accurate site-delivery of drug while reducing the risk of collateral damage to surrounding healthy tissue. Of the many strategies available to achieve these desirable effects, silica/gold nano-assemblies offers a practical means to achieving these aims. Herein, as a proof-of-concept, a silica nano-capsule passivated with a gold outer nanoshell had been fabricated to deliver Doxorubicin, and this nano-assembly can be remotely triggered via two-photon excitation (TPE), even under in vivo setting. A polyethylene glycol (PEG) layer as well as AS1411 DNA aptamer had also been grafted to the surface to improve homing specificity toward MDA-MB-231 breast cancer tissue. The assembly of silica/gold nanocapsules was characterized via TEM, FTIR, and UV-Vis to validate the the nanoconstruct. Upon TPE irradiation, a higher expression level of Annexin V and Caspase-3 was observed in both in vitro and in vivo animal models. A significant reduction in tumor size on mice model was noticed after 21 days, and these results had suggested a viable nano-sized design serving as remotely triggered drug release platform based on current well-established silica nanoparticulate methodologies.
    日期: 2022-03
    關聯: International Journal of Smart and Nano 13(1):79-99.
    Link to: http://dx.doi.org/10.1080/19475411.2022.2033874
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1947-5411&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000753805300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85125065941
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