國家衛生研究院 NHRI:Item 3990099045/14070
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 917826      在线人数 : 1321
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/14070


    题名: Upregulated heme biosynthesis increases obstructive sleep apnea severity: A pathway-based Mendelian randomization study
    作者: Wang, H;Kurniansyah, N;Cade, BE;Goodman, MO;Chen, H;Gottlieb, DJ;Gharib, SA;Purcell, SM;Lin, X;Saxena, R;Zhu, X;Durda, P;Tracy, R;Liu, Y;Taylor, KD;Johnson, WC;Gabriel, S;Smith, JD;Aguet, F;Ardlie, K;Blackwell, T;Reiner, AP;Rotter, JI;Rich, SS;Ayas, N;Burkardt, D;Cade, B;Chen, H;Clarkson-Townsend, D;Dutta, J;Ekunwe, L;Floyd, C;Gharib, S;Goodman, M;Gottlieb, D;Granot-Hershkovitz, E;Hale, L;Hanly, P;Heemann, S;Hsiung, C;Huang, T;Justice, A;Keenan, B;Lane, J;Liang, J;Lin, X;Liu, J;Lorincz-Comi, N;Magalang, U;Mazzotti, DR;Mei, H;Mikulla, J;Miller, A;Moafi-Madani, M;Ngo, D;O’Connell, J;Ochs-Balcom, H;Pack, A;Patel, S;Purcell, S;Redline, S;Saxena, R;Soemedi, R;Sofer, T;Sul, JH;Sunyaev, S;Tchio, C;Wang, H;Wilson, A;Xia, L;Zhang, M;Zhou, H;Zhu, X;Redline, S;Sofer, T;TOSTW Group
    贡献者: Institute of Population Health Sciences
    摘要: Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes in recent admixture mapping and gene enrichment analyses. However, its causal contribution was unclear. In this study, we performed pathway-level transcriptional Mendelian randomization (MR) analysis to investigate the causal relationships between iron and heme related pathways and OSA. In primary analysis, we examined the expression level of four iron/heme Reactome pathways as exposures and four OSA traits as outcomes using cross-tissue cis-eQTLs from the Genotype-Tissue Expression portal and published genome-wide summary statistics of OSA. We identify a significant putative causal association between up-regulated heme biosynthesis pathway with higher sleep time percentage of hypoxemia (p = 6.14 × 10–3). This association is supported by consistency of point estimates in one-sample MR in the Multi-Ethnic Study of Atherosclerosis using high coverage DNA and RNA sequencing data generated by the Trans-Omics for Precision Medicine project. Secondary analysis for 37 additional iron/heme Gene Ontology pathways did not reveal any significant causal associations. This study suggests a causal association between increased heme biosynthesis and OSA severity.
    日期: 2022-01-27
    關聯: Scientific Reports. 2022 Jan 27;12:Article number 1472.
    Link to: http://dx.doi.org/10.1038/s41598-022-05415-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85123904808
    显示于类别:[熊昭] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP85123904808.pdf2295KbAdobe PDF159检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈