Siblings 專利 [0/3] 會議論文/會議摘要 [0/2] Collection Statistics 近3年內發表的文件:3(14.29%) 含全文筆數:21(100.00%) 文件下載次數統計 下載大於0次:21(100.00%) 下載大於100次:19(90.48%) 檔案下載總次數:12143(100.00%) 最後更新時間: 2024-11-28 17:56 Top Upload Loading... Top Download Loading... Recent Submissions Discovery of a long half-life AURKA... Pulmonary delivery of remdesivir an... Modulating the affinity and signali... Synergistic inhibition of SARS-CoV-... Discovery and synthesis of a pyrimi... Synergistic inhibition of SARS-CoV-... Inhibition of SARS-CoV-2 by highly ... Comparative study between deep lear... Fluorine-18 isotope labeling for po... Design and synthesis of BPR1K653 de...

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Showing items 1-21 of 21. (1 Page(s) Totally) 1  View [10|25|50] records per page

Date	Title	Relation
2024-06-01	Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus	Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779.
2023-12	Pulmonary delivery of remdesivir and dexamethasone encapsulated nanostructured lipid carriers for enhanced inflammatory suppression in lung	Journal of Drug Delivery Science and Technology. 2023 Dec;90:Article number 105144.
2023-01	Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists	Bioorganic Chemistry. 2023 Jan;130:Article number 106236.
2021-06-11	Synergistic inhibition of SARS-CoV-2 replication using disulfiram/ebselen and remdesivir[Erratum:ACS Pharmacology and Translational Science. 2021 Apr 9;4(2):898-907.]	ACS Pharmacology and Translational Science. 2021 Jun 11;4(3):Article number 1246.
2021-05-19	Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins	Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330.
2021-04-09	Synergistic inhibition of SARS-CoV-2 replication using disulfiram/ebselen and remdesivir	ACS Pharmacology and Translational Science. 2021 Apr 9;4(2):898-907.
2020-12-14	Inhibition of SARS-CoV-2 by highly potent broad-spectrum anti-coronaviral tylophorine-based derivatives	Frontiers in Pharmacology. 2020 Dec 14;11:Article number 606097.
2020-10-08	Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery	Scientific Reports. 2020 Oct 8;10:Article number 16771.
2019-01-01	Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist	Bioorganic and Medicinal Chemistry. 2019 Jan 1;27(1):216-223.
2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	European Journal of Medicinal Chemistry. 2018 May 10;151:533-545.
2016-12-08	Bromomethylthioindole inspired carbazole hybrids as promising class of anti-MRSA agents	ACS Medicinal Chemistry Letters. 2016 Dec 8;7(12):1191-1196.
2015-05	A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis	Diabetes, Obesity and Metabolism. 2015 May;17(5):495-504.
2015-03	Stem cell mobilizers targeting chemokine receptor CXCR4: Renoprotective application in acute kidney injury	Journal of Medicinal Chemistry. 2015 Mar;58(5):2315-2325.
2015-02	Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors	Journal of Medicinal Chemistry. 2015 Feb;58(3):1452-1465.
2013-11-13	Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice	Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
2012-07	Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors	International Journal of Obesity. 2012 Jul;36(7):999-1006.
2012-02	Discovery of novel stem cell mobilizers that target the CXCR4 receptor	ChemMedChem. 2012 Feb;7(2):209-212.
2011-07	Conia-ene annulation of the alpha-cyano Beta-TMS-capped alkynyl cycloalkanone system and its synthetic application	Organic and Biomolecular Chemistry. 2011 Jul;9(13):4778-4781.
2010-09	Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist	ChemMedChem. 2010 Sep;5(9):1439-1443.
2009-07-23	Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice	Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510.
2008-09-11	Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists	Journal of Medicinal Chemistry. 2008 Sep 11;51(17):5397-5412.

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