國家衛生研究院 NHRI:Item 3990099045/1408
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1408


    Title: Methamphetamine-elicited alterations of dopamine- and serotonin-metabolite levels within mu-opioid receptor knockout mice: a microdialysis study
    Authors: Lan, KC;Ma, T;Lin-Shiau, SY;Liu, SH;Ho, IK
    Contributors: Division of Mental Health and Substance Abuse Research
    Abstract: mu-Opioid receptors (mu-ORs) modulate methamphetamine (MA)-induced behavioral responses, increased locomotor activity and stereotyped behavior in the mouse model. We investigated the changes in dopamine (DA) and serotonin (5-HT) metabolism in the striatum following either acute or repeated MA treatment using in vivo microdialysis. We also studied the role of mu-ORs in the modulation of MA-induced DA and 5-HT metabolism within mu-OR knockout mice. Subsequent to either acute or repeated intraperitoneal administration of MA, wild-type mice revealed decreases in extracellular concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner. Moreover, wild-type mice had reductions in basal concentrations of DOPAC and HVA following repeated MA treatment with a higher dose. The effects of acute, repeated or challenge MA administration upon extracellular levels of DOPAC and HVA within mu-OR knockout mice significantly differed from the wild-type controls. The duration of recovery to the basal levels of extracellular DA and 5-HT metabolites induced by MA were much longer in wild-type mice than for mu-OR knockout mice. These findings suggest that mu-ORs play a modulatory role in MA-induced DA and 5-HT metabolism in the mouse striatum. This possible mechanism of MA-induced behavioral change as modulated by mu-OR merits further study.
    Keywords: Medicine, Research & Experimental
    Date: 2008-05
    Relation: Journal of Biomedical Science. 2008 May;15(3):391-403.
    Link to: http://dx.doi.org/10.1007/s11373-007-9218-7
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-7770&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000255092500011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=42449145533
    Appears in Collections:[Ing-Kang Ho(2006-2011)] Periodical Articles

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