國家衛生研究院 NHRI:Item 3990099045/1410
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    題名: Therapeutic strategy at the crossroad of neuroinflammation and oxidative stress in age-related neurodegenerative diseases
    作者: Shie, FS;Ling, ZD
    貢獻者: Division of Mental Health and Substance Abuse Research
    摘要: Aging is the greatest risk factor for neurodegenerative diseases in the CNS, including two major age-related neuroclegenerative diseases, Alzheimer's disease and Parkinson's disease. Understanding the biology of aging is pivotal in management of patients with neuroclegenerative disorders. Genetically programmed aging and oxidative stress-elicited aging are two mechanisms of aging that are likely intertwined, leading to neuroclegenerative damages. It is a commonly accepted that neurodegenerative diseases are the consequences of overproduction of oxidative stress or a result of compromised antioxidative mechanisms regardless of their aetiology. In aged brain, microglia increase in number and switch to a more pro-inflammatory state, providing a basis for greater inflammatory responses to inflammogens. Unfortunately, these unfavorable changes are often coupled with compromised capacity to remove oxidative products, allowing mutual perpetuation of inflammation and oxidative damage. This review highlights roles of microglia-mediated neuroinflammation and oxidative stress and association of these two. The possible novel therapeutic approaches are discussed in the context of focusing only on those possessing anti-inflammatory or antioxidative properties.
    關鍵詞: Medicine, Legal;Pharmacology & Pharmacy
    日期: 2007-04
    關聯: Expert Opinion on Therapeutic Patents. 2007 Apr;17(4):419-428.
    Link to: http://dx.doi.org/10.1517/13543776.17.4.419
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1354-3776&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000245518300005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34147097583
    顯示於類別:[林兆東(2006-2009)] 期刊論文
    [謝奉勳] 期刊論文

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