國家衛生研究院 NHRI:Item 3990099045/14129
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14129


    Title: PERK is a critical metabolic hub for immunosuppressive function in macrophages
    Authors: Raines, LN;Zhao, HX;Wang, YZ;Chen, HY;Gallart-Ayala, H;Hsueh, PC;Cao, W;Koh, Y;Alamonte-Loya, A;Liu, PS;Ivanisevic, J;Lio, CWJ;Ho, PC;Huang, SCC
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Chronic inflammation triggers compensatory immunosuppression to stop inflammation and minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress augments the suppressive phenotypes of immune cells; however, the molecular mechanisms underpinning this process and how it links to the metabolic reprogramming of immunosuppressive macrophages remain elusive. In the present study, we report that the helper T cell 2 cytokine interleukin-4 and the tumor microenvironment increase the activity of a protein kinase RNA-like ER kinase (PERK)-signaling cascade in macrophages and promote immunosuppressive M2 activation and proliferation. Loss of PERK signaling impeded mitochondrial respiration and lipid oxidation critical for M2 macrophages. PERK activation mediated the upregulation of phosphoserine aminotransferase 1 (PSAT1) and serine biosynthesis via the downstream transcription factor ATF-4. Increased serine biosynthesis resulted in enhanced mitochondrial function and alpha-ketoglutarate production required for JMJD3-dependent epigenetic modification. Inhibition of PERK suppressed macrophage immunosuppressive activity and could enhance the efficacy of immune checkpoint programmed cell death protein 1 inhibition in melanoma. Our findings delineate a previously undescribed connection between PERK signaling and PSAT1-mediated serine metabolism critical for promoting immunosuppressive function in M2 macrophages.
    Date: 2022-02-28
    Relation: Nature Immunology. 2022 Feb 28;23(3):431-445.
    Link to: http://dx.doi.org/10.1038/s41590-022-01145-x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1529-2908&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000762163700003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85125317692
    Appears in Collections:[Pu-Ste Liu] Periodical Articles

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