國家衛生研究院 NHRI:Item 3990099045/14133
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    题名: Radiometal-labeled chitosan microspheres as transarterial radioembolization agents against hepatocellular carcinoma
    作者: Chan, HW;Lo, YH;Chang, DY;Li, JJ;Chang, WY;Chen, CH;Chang, CH;Chen, CL;Wang, HE;Liu, RS;Wu, CY
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Transarterial radioembolization (TARE) is an emerging treatment for patients with unresectable hepatocellular carcinoma (HCC). This study successfully developed radiometal-labeled chitosan microspheres ((111)In/(177)Lu-DTPA-CMS) with a diameter of 36.5 ± 5.3 μm for TARE. The radiochemical yields of (111)In/(177)Lu-DTPA-CMS were greater than 90% with high radiochemical purities (>98%). Most of the (111)In/(177)Lu-DTPA-CMS were retained in the hepatoma and liver at 1 h after intraarterial (i.a.) administration. Except for liver accumulation, radioactivity in each normal organ was less than 1% of the injected radioactivity (%IA) at 72 h after injection. At 10 days after injection of (177)Lu-DTPA-CMS (18.6 ± 1.3 MBq), the size of the hepatoma was significantly reduced by around 81%, while that of the rats in the control group continued to grow. This study demonstrated the effectiveness of (177)Lu-DTPA-CMS in the treatment of N1-S1 hepatoma. (111)In/(177)Lu-DTPA-CMS have the potential to be a superior theranostic pair for the treatment of clinical hepatoma.
    日期: 2022-03-14
    關聯: Gels. 2022 Mar 14;8(3):Article number 180.
    Link to: http://dx.doi.org/10.3390/gels8030180
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2310-2861&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000775317400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85127025286
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