國家衛生研究院 NHRI:Item 3990099045/14167

NHRI > National Institute of Environmental Health Sciences > Yue-Liang Guo > Periodical Articles > Item 3990099045/14167

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14167

Title:	Living proximity to petrochemical industries and the risk of attention-deficit/hyperactivity disorder in children
Authors:	Huang, CC;Pan, SC;Chin, WS;Chen, YC;Wu, CD;Hsu, CY;Lin, P;Chen, PC;Guo, YL
Contributors:	National Institute of Environmental Health Sciences
Abstract:	Evidence regarding the negative neurodevelopmental effects of compound exposure to petrochemicals remains limited. We aimed to evaluate the association between exposure to petrochemical facilities and generated emissions during early life and the risk of attention-deficit/hyperactivity disorder (ADHD) development in children. We conducted a population-based birth cohort study using the 2004 to 2014 Taiwanese Birth Certificate Database and verified diagnoses of ADHD using the National Health Insurance Database. The level of petrochemical exposure in each participant's residential township was evaluated using the following 3 measurements: distance to the nearest petrochemical industrial plant (PIP), petrochemical exposure probability (accounting for monthly prevailing wind measurements), and monthly benzene concentrations estimated using kriging-based land-use regression models. We applied Cox proportional hazard models to evaluate the association. During the study period, 48,854 out of 1,863,963 children were diagnosed as having ADHD. The results revealed that residents of townships in close proximity to PIPs (hazard ratio [HR] = 1.20, 95% confidence interval [CI]: 1.16-1.23, <3 vs. ≥10 km), highly affected by petrochemical-containing prevailing winds (HR = 1.12, 95% CI: 1.08-1.16, ≥40% vs. <10%), and with high benzene concentrations (HR = 1.26, 95% CI: 1.23-1.29, ≥0.75 vs. <0.55 ppb) were consistently associated with the increased risk of ADHD development in children. The findings of the sensitivity analysis remained robust, particularly for the 2004 to 2009 birth cohort and for models accounting for a longer duration of postnatal exposure. This work provided clear evidence that living near petrochemical plants increases the risk of ADHD development in children. Further studies are warranted to confirm our findings.
Date:	2022-09
Relation:	Environmental Research. 2022 Sep;212(Part. A):Article number 113128.
Link to:	http://dx.doi.org/10.1016/j.envres.2022.113128
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0013-9351&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000793114500007
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85126957487
Appears in Collections:	[Yue-Liang Guo] Periodical Articles [Pau-Chung Chen] Periodical Articles [Pinpin Lin] Periodical Articles [Yu-Cheng Chen] Periodical Articles

Files in This Item:

File	Description	Size	Format
PUB35337833.pdf		1438Kb	Adobe PDF	225	View/Open

Loading...