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http://ir.nhri.org.tw/handle/3990099045/14207
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| Title: | Novel insights into the anti-cancer effects of 3-bromopyruvic acid against castration-resistant prostate cancer |
| Authors: | Yeh, HC;Su, CC;Wu, YH;Lee, CH;Bao, BY;Cheng, WC;Wang, SC;Liu, PL;Chiu, CC;Chuu, CP;Ke, CC;Wu, HE;Chen, YR;Chung, WJ;Huang, SP;Li, CY |
| Contributors: | Institute of Cellular and Systems Medicine |
| Abstract: | 3-bromopyruvic acid (3-BP), a small molecule alkylating agent, has been emerged as a glycolytic inhibitor with anticancer activities. However, the effects of 3-BP on the growth and metastasis in prostate cancer have not been well investigated. Here we investigated the anti-cancer effects of 3-BP on prostate cancer in vitro and in vivo. Cell growth, apoptosis, migration, motility, and invasion were examined. The tumor growth ability was determined using a xenograft murine model. Transcriptome analysis using RNA-seq was performed to explore the mechanism of action of 3-BP. Our experimental results showed that 3-BP effectively inhibits prostate cancer cell growth, especially in castration-resistant prostate cancer (CRPC) cells. Moreover, 3-BP induces apoptosis and suppresses cell migration, motility, epithelial-mesenchymal transition (EMT), and invasion in CRPC cells. In addition, 3-BP also attenuates tumor growth in a xenograft murine model. Through transcriptome analysis using RNA-seq, 3-BP significantly regulates the cell cycle pathway and decreases the expression of downstream cycle cycle-associated genes in CRPC cells. The results of cell cycle analysis indicated that 3-BP arrests cell cycle progression at G2/M in CRPC cells. These results suggest that 3-BP has the potential in inhibiting CRPC progression and might be a promising drug for CRPC treatment. |
| Date: | 2022-05-15 |
| Relation: | European Journal of Pharmacology. 2022 May 15;923:Article number 174929. |
| Link to: | http://dx.doi.org/10.1016/j.ejphar.2022.174929 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-2999&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000806938300001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85127335871 |
| Appears in Collections: | [褚志斌] 期刊論文
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| SCP85127335871.pdf | | 10980Kb | Adobe PDF | 166 | View/Open |
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