國家衛生研究院 NHRI:Item 3990099045/14211
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    題名: Genetic relatedness among azole-resistant Candida tropicalis clinical strains in Taiwan from 2014 to 2018
    作者: Zhou, ZL;Tseng, KY;Chen, YZ;Tsai, DJ;Wu, CJ;Chen, YC;Peng, HL;Yang, YL;Hsieh, LY;Chen, CH;Hsu, CH;Wang, LS;Cheng, MF;Hsu, GJ;Kao, CC;Hu, BS;Lee, YT;Liu, JW;Liu, KS;Miu, WC;Yang, HM;Yeh, YC;Lo, HJ
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: To monitor trends in the distributions of yeast species and susceptibilities of those species to commonly prescribed antifungal drugs, we conduct the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) every four years. We found that 25 of the 294 Candida tropicalis from TSARY 2014 and 31 of the 314 C. tropicalis from TSARY 2018 were resistant to fluconazole. We determined the genetic relatedness among fluconazole-resistant C. tropicalis by multilocus sequence typing. Of the 174 C. tropicalis isolates, including all 56 fluconazole-resistant, all 26 -susceptible-dose dependent, and 92 selected fluconazole-susceptible isolates, 59 diploid sequence types (DSTs) were identified. We found that 22 of the 25 and 29 of the 31 fluconazole-resistant C. tropicalis from TSARY 2014 and 2018, respectively, were genetically related and belonged to the same cluster: clade 4. A combination of mutation and overexpression of ERG11, the target of azole drugs, was the major mechanism contributing to drug resistance. Approximately two thirds of reviewed patients infected/colonized by fluconazole-resistant C. tropicalis were azole-naïve. Furthermore, there was no evidence of patient-to-patient transmission. Because the clade 4 fluconazole-resistant C. tropicalis strain persists in Taiwan, it is important to identify the source of azole-resistant C. tropicalis to prevent the spread of this resistant strain.
    日期: 2022-06
    關聯: International Journal of Antimicrobial Agents. 2022 Jun;59(6):Article number 106592.
    Link to: http://dx.doi.org/10.1016/j.ijantimicag.2022.106592
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000806713200003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85130409636
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