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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/14252
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| Title: | Mesoporous Silica Nanoparticles (MSNs) for cancer theranostics |
| Authors: | Hsia, Y;Sivasubramanian, M;Chen, NT;Lo, LW |
| Contributors: | Institute of Biomedical Engineering and Nanomedicine |
| Abstract: | Optimizing the balance between therapeutic efficacy and side effects is a major challenge in developing drugs. To circumvent unwanted side effects, nanoformulation of drugs for targeted delivery and controlled release is being researched and developed actively in translational nanomedicine. Among the various organic, inorganic, and hybrid nanomaterials used in formulating drugs, mesoporous silica nanoparticles (MSNs) have been drawing increasing attention because they provide a solid framework with a mesoporous structure and a high surface area that can be modified with diverse functional groups to control morphology. MSNs possess 3 topological domains, framework, nanochannels, and outermost surface, each of which can be functionalized sequentially with distinct moieties, making MSN a unique theranostic nanoplatform. The modified functional groups on the surface allow MSNs to be conjugated with diverse targeting molecules, peptides, and aptamers for efficient uptake and accumulation by specific target sites. Furthermore, to release the incorporated drug payload, nanochannels in MSNs can be controlled by varying external and/or internal stimuli, for example by photoirradiating or by altering the pH of subcellular domains and tumor microenvironments. Multifunctionalized MSNs have been proven to be a key platform for 3-in-1 nanotheranostics that orchestrates traceable imaging, targeted delivery, and selective therapeutics for cancer treatments. |
| Date: | 2016-02-22 |
| Relation: | Nanomaterials for Tumor Targeting Theranostics: A Proactive Clinical Perspective. 2016 Feb 22:143-176. |
| Link to: | http://dx.doi.org/10.1142/9789814635424_0005 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85128578664 |
| Appears in Collections: | [羅履維] 圖書
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| SCP85128578664.pdf | | 18924Kb | Adobe PDF | 141 | View/Open |
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