國家衛生研究院 NHRI:Item 3990099045/14264

NHRI > National Institute of Infectious Diseases and Vaccinology > Huey-Kang Sytwu > Periodical Articles > Item 3990099045/14264

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14264

Title:	Association between depression or anxiety and the risk of hepatitis B flares: A nationwide population-based cohort study
Authors:	Tsai, MK;Sytwu, HK;Hsieh, TY;Chien, WC;Lai, CH;Chen, HC
Contributors:	National Institute of Infectious Diseases and Vaccinology
Abstract:	PURPOSE: Depression and anxiety have been reported to increase the risk of infectious diseases and reactivation of latent infection. We conducted a nationwide population-based retrospective cohort study to determine the relationship between hepatitis B flares and depression or anxiety, utilizing outpatient and inpatient data from the Taiwan National Health Insurance Research database collected from 2000 to 2015. PATIENTS AND METHODS: A total of 12,992 patients with chronic hepatitis B and newly diagnosed anxiety/depression, without advanced liver disease, were propensity score-matched for age, sex, and comorbidities in a 1:4 ratio to 51,968 controls with chronic hepatitis B without depression/anxiety or advanced liver disease. Both groups were followed-up until December 31, 2015. Cox proportional hazards regression was used to determine the risk factors for hepatitis B flares. The Log rank test and Kaplan-Meier analysis were performed to assess differences in the cumulative incidence of hepatitis B flares according to anxiety/depression status. RESULTS: The incidence of hepatitis B flares was higher in the depression/anxiety cohort than in the control cohort (log-rank; p < 0.001). Patients with depression/anxiety had a significantly higher incidence rate of hepatitis B flares than those without depression/anxiety (3017 per 10(5) person-years versus 2042 per 10(5) person-years, p = 0.003). After adjusting for age and comorbidities, anxiety/depression was independently associated with an increased risk of hepatitis B flares (hazard ratio, 1.173; 95% confidence interval, 1.033-1.277; p = 0.003). CONCLUSION: This analysis suggests that in patients with chronic hepatitis B without advanced liver disease, those with concomitant depression or anxiety may be at higher risk of hepatitis B flares.
Date:	2022-05-19
Relation:	Journal of Inflammation Research. 2022 May 19;15:2983-2993.
Link to:	http://dx.doi.org/10.2147/jir.S355314
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1178-7031&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000800654300001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85131063568
Appears in Collections:	[Huey-Kang Sytwu] Periodical Articles

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