國家衛生研究院 NHRI:Item 3990099045/14266

NHRI > National Institute of Infectious Diseases and Vaccinology > Wang-Chou Sung > Periodical Articles > Item 3990099045/14266

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14266

Title:	Cytotoxicity of venoms and cytotoxins from asiatic cobras (Naja kaouthia, Naja sumatrana, Naja atra) and neutralization by antivenoms from Thailand, Vietnam, and Taiwan
Authors:	Chong, HP;Tan, KY;Liu, BS;Sung, WC;Tan, CH
Contributors:	National Institute of Infectious Diseases and Vaccinology
Abstract:	Envenoming by cobras (Naja spp.) often results in extensive local tissue necrosis when optimal treatment with antivenom is not available. This study investigated the cytotoxicity of venoms and purified cytotoxins from the Monocled Cobra (Naja kaouthia), Taiwan Cobra (Naja atra), and Equatorial Spitting Cobra (Naja sumatrana) in a mouse fibroblast cell line, followed by neutralization of the cytotoxicity by three regional antivenoms: the Thai Naja kaouthia monovalent antivenom (NkMAV), Vietnamese snake antivenom (SAV) and Taiwanese Neuro bivalent antivenom (NBAV). The cytotoxins of N. atra (NA-CTX) and N. sumatrana (NS-CTX) were identified as P-type cytotoxins, whereas that of N. kaouthia (NK-CTX) is S-type. All venoms and purified cytotoxins demonstrated varying concentration-dependent cytotoxicity in the following trend: highest for N. atra, followed by N. sumatrana and N. kaouthia. The antivenoms moderately neutralized the cytotoxicity of N. kaouthia venom but were weak against N. atra and N. sumatrana venom cytotoxicity. The neutralization potencies of the antivenoms against the cytotoxins were varied and generally low across NA-CTX, NS-CTX, and NK-CTX, possibly attributed to limited antigenicity of CTXs and/or different formulation of antivenom products. The study underscores the need for antivenom improvement and/or new therapies in treating local tissue toxicity caused by cobra envenomings.
Date:	2022-05-10
Relation:	Toxins. 2022 May 10;14(5):Article number 334.
Link to:	http://dx.doi.org/10.3390/toxins14050334
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2072-6651&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000803315900001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85130396017
Appears in Collections:	[Wang-Chou Sung] Periodical Articles

Files in This Item:

File	Description	Size	Format
SCP85130396017.pdf		5314Kb	Adobe PDF	166	View/Open

Loading...