國家衛生研究院 NHRI:Item 3990099045/14277
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14277


    Title: Evaluating the effectiveness of population-based breast cancer service screening: An analysis of parsimonious patient survival information with the time-varying Cox model
    Authors: Chang, WJ;Jen, HH;Lin, KC;Cheng, TC;Chuang, SY;Pan, SL;Chen, HH;Yen, MF
    Contributors: Institute of Population Health Sciences
    Abstract: BACKGROUND: This study is aimed at estimating the unbiased effectiveness of population-based breast cancer service screening based on case survival information alone rather than large-scale individual screening data pursuant to the intention-to-treat principle of a randomized-controlled trial. METHODS: A novel time-dependent switched design with two modalities of cancer detection (screen-detected vs clinically detected) was proposed to evaluate the effectiveness of breast cancer screening. We used data on 767 patients from Kopparberg in the Swedish Two-County trial and on 78 587 patients in the Taiwan population-based service screening. We estimated the relative rate of the screen-detected vs the clinically detected with adjustment for both truncation and lead-time biases. The absolute effectiveness in terms of the number needed to screen (NNS) for averting one death from breast cancer was estimated. RESULTS: The relative rate of effectiveness was estimated as 33%, which was consistent with the 37% reported from the original Swedish randomized-controlled trial. The corresponding estimate for the Taiwan screening programme was 42%, which was also very close to that estimated using individual screening history data (41%). Both relative estimates were further applied to yield 446 and 806 of NNS for averting one death from breast cancer for the corresponding two data sets. CONCLUSION: The proposed time-dependent switched design and analysis with two modalities of case survival information provides a very efficient means for estimating the unbiased estimates of relative and absolute effectiveness of population-based breast cancer service screening dispensing with a large amount of individual screening history data.
    Date: 2022-12
    Relation: International Journal of Epidemiology. 2022 Dec 13;51(6):1910-1919.
    Link to: http://dx.doi.org/10.1093/ije/dyac096
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0300-5771&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000794925500001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85144585797
    Appears in Collections:[Shao-Yuan Chuang] Periodical Articles

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