國家衛生研究院 NHRI:Item 3990099045/1427
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1427


    Title: Association study of polymorphisms in post-synaptic density protein 95 (PSD-95) with schizophrenia
    Authors: Tsai, SJ;Hong, CJ;Cheng, CY;Liao, DL;Liou, YJ
    Contributors: Division of Mental Health and Substance Abuse Research
    Abstract: The postsynaptic density protein 95 (PSD-95) - the prototype of this family - is a modular protein that enables anchoring of NMDA receptors, modulates NMDA receptor sensitivity to glutamate and coordinates NMDA receptor-related intracellular processes. Since hypofunction of NMDA receptors has been implicated in the pathophysiology of schizophrenia, we explored the hypothesis that genetic variants of the PSD-95 gene were associated with a diagnosis of schizophrenia. Three PSD-95 polymorphisms were studied in a sample population of 248 people with schizophrenia and 208 normal controls. One polymorphism (rs373339) was not informative in our Chinese population while the other two polymorphisms (rs2521985 and rs17203281) were analysed with chi-square tests and haplotype analysis. Results demonstrated that the two informative polymorphisms are in strong linkage disequilibrium with each other. Neither single marker nor haplotype analysis revealed an association between variants at the PSD-95 locus and schizophrenia, suggesting that it is unlikely that the PSD-95 polymorphisms investigated play a substantial role in conferring susceptibility to schizophrenia in the Chinese population. Further genetic studies in schizophrenia with other PSD-95-like molecules that interact with the glutamate system are suggested.
    Keywords: Clinical Neurology;Neurosciences
    Date: 2007-04
    Relation: Journal of Neural Transmission. 2007 Apr;114(4):423-426.
    Link to: http://dx.doi.org/10.1007/s00702-006-0587-2
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0300-9564&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000245133400004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33947529134
    Appears in Collections:[Ding-Lieh Liao(2005-2008)] Periodical Articles

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