國家衛生研究院 NHRI:Item 3990099045/14289
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    題名: WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour
    作者: Chen, SL;Liu, BT;Lee, WP;Liao, SB;Deng, YB;Wu, CL;Ho, SM;Shen, BX;Khoo, GH;Shiu, WC;Chang, CH;Shih, HW;Wen, JK;Lan, TH;Lin, CC;Tsai, YC;Tzeng, HF;Fu, TF
    貢獻者: Center for Neuropsychiatric Research;National Institute of Infectious Diseases and Vaccinology
    摘要: The authors show that the Drosophila master regulator WAKE modulates the secretion of insulin-like peptides, triggering a decrease in 20-hydroxyecdysone levels. This lowers the perception of a male-specific sex pheromone and explains why WAKE-deficient Drosophila flies show male-male courtship behaviour. The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABA(A) receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.
    日期: 2022-05-06
    關聯: Nature Communications. 2022 May 6;13:Article number 2518.
    Link to: http://dx.doi.org/10.1038/s41467-022-30165-2
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000791826000006
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85129768890
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