國家衛生研究院 NHRI:Item 3990099045/14312
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    题名: Aspalathus linearis suppresses AKT signaling, c-Myc, AR and survival of enzalutamide-resistant prostate cancer cells
    作者: Chih-Pin, C;Huang, S-H;Muller, C;Wang, B-J;Chang, K-S
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Enzalutamide, a nonsteroidal antiandrogen, significantly prolonged the survival of patient with metastatic castration-resistant prostate cancer (CRPC). However, patients receiving enzalutamide frequently develop drug resistance within 1-2 years. Rooibos (Aspalathus linearis) is a shrub-like leguminous fynbos plant endemic to the Cedarberg Mountains area in South Africa. We examined if GRT may suppress the enzalutamide-resistant LNCaP C4-2 MDV3100r cells. GRT dose-dependently suppressed the proliferation, colony formation, cell cycle progression as well as induced apoptosis in MDV3100r cells. GRT suppressed the protein expression level of Akt, PI3Kα, PI3Kγ, PDK1, phospho-PDK1 S241, Skp2, cyclin D1, AR, phos-pho-AR S81, Cdk1, pro-PARP, cMyc and Bcl-2 but increased abundance of caspase 3 and cleaved-PARP. GRT reduced the abundance of AR proteins both in nucleus and cytoplasm of MDV3100r cells. Overexpression of AKT and c-Myc partially antagonized the suppressive effects of GRT Our study suggested that GRT may be useful for preventing enzalutamide resistance.
    日期: 2022-02
    關聯: Cancer Science. 2022 Feb;113(S1):1338.
    Link to: https://doi.org/10.1111/cas.15292
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000778583803216
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