國家衛生研究院 NHRI:Item 3990099045/14334
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    题名: An anti-inflammatory electroconductive hydrogel with self-healing property for the treatment of Parkinson’s disease
    作者: Xu, JP;Tai, CH;Chen, TY;Hsu, SH
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Parkinson's disease (PD) is one of the most common neurodegenerative diseases with the characteristics of a progressive loss of dopaminergic neurons. Biomaterials employed in the treatment of PD are challenging and still limited. Herein, we designed and synthesized conductive hydrogels with the self-healing and anti-inflammatory properties from dialdehyde polyurethane (-36 nm) nanocrosslinker, gold nanoparticles (-15 nm), and O-carboxymethyl chitosan under physiological conditions. These hydrogels showed stable crosslinking network, proper conductivity (2-4 mS/cm), small-gauge needle (30G) injectability, and good biodegradability. Furthermore, the hydrogel promoted the proliferation and differentiation of neural stem cells (NSCs) towards neuronal cells. The anti-inflammatory effect and rescue function on inflammatory NSCs (-80%) were also demonstrated in vitro. Animal experiments confirmed that injection of the conductive hydrogel in the brain recovered the motor function of the PD rats, signified by the relief of the spontaneous circling speed and impaired forelimb usage. Histological analyses showed that injection of the conductive hydrogel increased the density of tyrosine hydroxylase positive neurons and fibers, as well as reduced the inflammatory responses. The in vitro and in vivo findings indicate that this conductive, self-healing, and biodegradable hydrogel with anti-inflammatory nanocomponents may serve as a promising vehicle without additional cells or drugs for the treatment of PD.
    日期: 2022-10-15
    關聯: Chemical Engineering Journal. 2022 Oct 15;446(Part 3):Article number 137180.
    Link to: http://dx.doi.org/10.1016/j.cej.2022.137180
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1385-8947&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000810450000002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85131655988
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