國家衛生研究院 NHRI:Item 3990099045/1433
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    题名: A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attention
    作者: Liu, YL;Fann, CSJ;Liu, CM;Chen, WJ;Wu, JY;Hung, SL;Chen, CH;Jou, YS;Liu, SK;Hwang, TJ;Hsieh, MH;Ouyang, WC;Chan, HY;Chen, JJ;Yang, WC;Lin, CY;Lee, SFC;Hwu, HG
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Background: The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. Methods: We selected 120 SNPs covering 1 Mb around D1S251 from the public database. These selected SNPs were initially validated if allele frequency was > 10%. Forty-seven validated SNPs were genotyped in 102 families with at least 2 siblings affected with schizophrenia. Results: Two SNP blocks showed significant association with schizophrenia. Block 1 (five-SNP), located between intron 2 and intron 13 of the glyceronephosphate O-acyltransferase (GNPAT) gene, showed the most significant associations using single-locus TDT (z = -2.0 7, p = .038, df = 1) and baplotype association analyses (z = -.1.99, p = .046, df = 1). Block 2 (two-SNP), located between intron 4 and intron 5 of the disrupted-in-schizophrenia 1 (DISC1) gene, also showed the most significant results in both the single-locus ( z = -3.22, p = .0013, df = 1) and haplotype association analyses (z = 3.35, p = .0008, df = 1). The association of the DISC1 gene with schizophrenia was mainly in the patient group with sustained attention deficits as assessed by the Continuous Performance Test. Conclusions: Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia, and DISCI is associated with sustained attention deficits.
    关键词: Neurosciences;Psychiatry
    日期: 2006-09-15
    關聯: Biological Psychiatry. 2006 Sep;60(6):554-562.
    Link to: http://dx.doi.org/10.1016/j.biopsych.2006.04.024
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-3223&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000240840700006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748741474
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