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    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1434


    題名: No association of G72 and D-amino acid oxidase genes with schizophrenia
    作者: Liu, YL;Fann, CSJ;Liu, CM;Chang, CC;Wu, JY;Hung, SI;Liu, SK;Hsieh, MH;Hwang, TJ;Chan, HY;Chen, JJ;Faraone, SV;Tsuang, MT;Chen, WJ;Hwu, HG
    貢獻者: Division of Mental Health and Substance Abuse Research
    摘要: The genes Of D-amino acid oxidase (DAAO) activator (DAOA or G72; 13q34) and DAAO (12q24) have been suggested as candidate genes and involved in the N-methyl-D-aspartate receptor regulation pathway for schizophrenia. In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia. In SNP-based single locus association analyses, neither G72 nor DAAO showed significant association with schizophrenia. Additionally, a three-SNP haplotype in DAAO, and a four-SNP as well as a two-SNP haplotype in G72, showed no significant associations with schizophrenia. These results suggest that the DAAO and G72 genes are not susceptibility genes for schizophrenia in a Taiwanese sample. (c) 2006 Elsevier B.V. All rights reserved.
    關鍵詞: Psychiatry
    日期: 2006-10
    關聯: Schizophrenia Research. 2006 Oct;87(1-3):15-20.
    Link to: http://dx.doi.org/10.1016/j.schres.2006.06.020
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0920-9964&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241310100003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748905941
    顯示於類別:[劉玉麗] 期刊論文

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