國家衛生研究院 NHRI:Item 3990099045/1435
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    题名: No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families
    作者: Liu, CM;Liu, YL;Fann, CSJ;Yang, WC;Wu, JY;Hung, SI;Chen, WJ;Chueh, CM;Liu, WM;Liu, CC;Hsieh, MH;Hwang, TJ;Faraone, SV;Tsuang, MT;Hwu, HG
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Several linkage studies have shown significant linkage of schizophrenia to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 (DTNBP1). The aim was to examine the association evidence of the candidate gene in 693 Taiwanese families with at least two affected siblings of schizophrenia. We genotyped nine SNPs of this gene with average intermarker distance of 17 kb. Intermarker linkage disequilibrium was calculated with GOLD. Single locus and haplotype association analyses were performed with TRANSMIT program. We found no significant association between schizophrenia and DTNBP1 either through single locus or haplotype analyses. We failed to replicate the association evidence between DTNBP1 and schizophrenia and this gene may not play a major role in the etiology of schizophrenia in this Taiwanese family sample. (c) 2007 Elsevier B.V. All rights reserved.
    关键词: Psychiatry
    日期: 2007-07
    關聯: Schizophrenia Research. 2007 Jul;93(1-3):391-398.
    Link to: http://dx.doi.org/10.1016/j.schres.2007.02.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0920-9964&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000247663200045
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34249302041
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