English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 907372      Online Users : 934
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14363


    Title: Di-(2-ethylhexyl) phthalate promotes allergic lung inflammation by modulating CD8a(+) dendritic cell differentiation via metabolite MEHP-PPARgamma axis
    Other Titles: Di-(2-ethylhexyl) phthalate promotes allergic lung inflammation by modulating CD8a(+) dendritic cell differentiation via metabolite MEHP-PPARγ axis
    Authors: Tseng, HH;Li, CY;Wu, ST;Su, HH;Wong, TH;Wu, HE;Chang, YW;Huang, SK;Tsai, EM;Suen, JL
    Contributors: National Institute of Environmental Health Sciences
    Abstract: Di-(2-ethylhexyl) phthalate (DEHP), a common plasticizer, is a ubiquitous environmental pollutant that can disrupt endocrine function. Epidemiological studies suggest that chronic exposure to DEHP in the environment is associated with the prevalence of childhood allergic diseases; however, the underlying causal relationship and immunological mechanism remain unclear. This study explored the immunomodulatory effect of DEHP on allergic lung inflammation, while particularly focusing on the impact of DEHP and its metabolite on dendritic cell differentiation and activity of peroxisome proliferator-activated receptor gamma (PPAR gamma). The results showed that exposure to DEHP at a human tolerable daily intake dose exacerbated allergic lung inflammation in mice. Ex vivo flow cytometric analysis revealed that DEHP-exposed mice displayed a significantly decreased number of CD8 alpha(+) dendritic cells (DCs) in spleens and DC progenitors in the bone marrow, as well as, less interleukin-12 production in splenic DCs and increased T helper 2 polarization. Pharmacological experiments showed that mono-(2-ethylhexyl) phthalate (MEHP), the main metabolite of DEHP, significantly hampered the differentiation of CD8 alpha(+) DCs from Fms-like tyrosine kinase 3 ligand-differentiated bone marrow culture, by modulating PPAR gamma activity. These results suggested that chronic exposure to DEHP at environmentally relevant levels, promotes allergic lung inflammation, at least in part, by altering DC differentiation through the MEHP-PPAR gamma axis. This study has crucial implications for the interaction(s) between environmental pollutants and innate immunity, with respect to the development of allergic asthma.
    Date: 2022-05-19
    Relation: Frontiers in Immunology. 2022 May 19;13:Article number 581854.
    Link to: http://dx.doi.org/10.3389/fimmu.2022.581854
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-3224&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000806558800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85131346341
    Appears in Collections:[黃嘯谷] 期刊論文

    Files in This Item:

    File Description SizeFormat
    ISI000806558800001.pdf9974KbAdobe PDF268View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback