國家衛生研究院 NHRI:Item 3990099045/1436
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    题名: More evidence supports the association of PPP3CC with schizophrenia
    作者: Liu, YL;Fann, CSJ;Liu, CM;Chang, CC;Yang, WC;Hung, SI;Yu, SL;Hwang, TJ;Hsieh, MH;Liu, CC;Tsuang, MM;Wu, JY;Jou, YS;Faraone, SV;Tsuang, MT;Chen, WJ;Hwu, HG
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Calcineurin is a calcium/calmodulin-dependent protein phosphatase composed of two subunits, a regulatory subunit of calcineurin B (CNB) and a catalytic subunit of calcineurin A (CNA). PPP3CC is the gamma isoform of CNA located at the chromosome 8p21.3 region. To evaluate the association between PPP3CC and schizophrenia in the Taiwanese population, 10 single nucleotide polymorphism ( SNP) markers across the gene were genotyped by the method of MALDI-TOF in 218 schizophrenia families with at least two affected siblings. One SNP (rs2272080) located around the exon 1 untranslated region was nominally associated with schizophrenia (P = 0.024) and significantly associated with the expression of PPP3CC in lymphoblast cell line; the TT and TG genotype had significantly higher relative expression levels than the GG genotype (P = 0.0012 and 0.015, respectively). In further endophenotype stratification, the single locus of rs2272080 and the haplotypes of both two-SNP haplotype (rs7833266-rs2272080) and seven-SNP haplotype (rs2461491-rs2469758-rs2461489 rs2469770-rs2449340-rs1482337-rs2252471) showed significant associations with the subgroup of schizophrenia with deficits of the sustained attention as tested by the continuous performance test (CPT, P < 0.05) and the executive functioning as tested by the Wisconsin Card Sorting Test (WCST, P < 0.05). The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia.
    关键词: Biochemistry & Molecular Biology;Neurosciences;Psychiatry
    日期: 2007-10
    關聯: Molecular Psychiatry. 2007 Oct;12(10):966-974.
    Link to: http://dx.doi.org/10.1038/sj.mp.4001977
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1359-4184&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000249920500014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34748834638
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