國家衛生研究院 NHRI:Item 3990099045/14399

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Title:	Development of a cross-conjugated vinylogous [4+2] anionic annulation and application to the total synthesis of natural antibiotic (±)-ABX
Authors:	Huang, JK;Shia, KS
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	The cross-conjugated vinylogous [4+2] anionic annulation has been newly developed, the cascade process of which has a high preference for regiochemical control and chemoselectivity, giving rise to exclusively Michael-type adducts in moderate to high yields (up to 94%, 35 examples). By making use of this approach as a key operation, the first total synthesis of natural antibiotic ABX, in racemic form, has been successfully achieved in a concise 7-step sequence with an overall yield of about 20%.
Date:	2020-01-16
Relation:	Advanced Materials. 2020 Jan 16;132(16):6602-6607.
Link to:	http://dx.doi.org/10.1002/ANGE.201914657
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0935-9648&DestApp=IC2JCR
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85134875624
Appears in Collections:	[Kak-Shan Shia] Periodical Articles

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