國家衛生研究院 NHRI:Item 3990099045/14415
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    题名: Metformin and the development of asthma in patients with type 2 diabetes
    作者: Yen, FS;Hsu, CC;Shih, YH;Pan, WL;Wei, JCC;Hwu, CM
    贡献者: Institute of Population Health Sciences
    摘要: We conducted this study to compare the risks of asthma development and exacerbation between metformin users and nonusers. Overall, 57,743 propensity score-matched metformin users and nonusers were identified from Taiwan's National Health Insurance Research Database between 1 January 2000, and 31 December 2017. We used the Cox proportional hazards model with robust standard error estimates to compare the risks of asthma onset, exacerbation, and hospitalization for asthma in participants with type 2 diabetes (T2D). Compared with metformin nonuse, the aHRs (95% CI) for metformin use in asthma development, exacerbation, and hospitalization for asthma were 1.13 (1.06-1.2), 1.62 (1.35-1.95), and 1.5 (1.22-1.85), respectively. The cumulative incidences of asthma development, exacerbation, and hospitalization for asthma were significantly higher in metformin users than nonusers (p < 0.001). A longer cumulative duration of metformin use for more than 728 days was associated with significantly higher risks of outcomes than metformin nonuse. Our study demonstrated that metformin users showed significantly higher risks of asthma development, exacerbation, and hospitalization for asthma than metformin nonusers. Moreover, metformin use for more than 728 days was associated with higher risks of outcomes. A randomized control study is warranted to verify our results.
    日期: 2022-07-05
    關聯: International Journal of Environmental Research and Public Health. 2022 Jul 5;19(13):Article number 8211.
    Link to: http://dx.doi.org/10.3390/ijerph19138211
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000823564900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85133379305
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