國家衛生研究院 NHRI:Item 3990099045/1444
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    题名: Genetic analysis of the human ENTH (Epsin 4) gene and schizophrenia
    作者: Liou, YJ;Lai, IC;Wang, YC;Bai, YM;Lin, CC;Lin, CY;Chen, TT;Chen, JY
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Numerous linkage studies suggest that chromosome 5q may be one of the important cytogenetic regions containing risk loci for schizophrenia susceptibility. Recently, genetic variations (rs254664 and rs10046055) in the intron 1 and 5' flanking regions of the ENTH (also known as Epsin 4) gene, which is located in 5q 33.3, have been demonstrated to be significantly associated with schizophrenia. The present study investigates whether this finding could be replicated in a population of Han Chinese, consisting of 269 patients with schizophrenia and 236 normal controls, by analyzing 9 single nucleotide polymorphisms (SNPs) ranging from the 5' upstream region to intron 8 of the ENTH gene and covering 96kb. The results showed that we failed to identify the associations of rs1186922 and rs10046055 with schizophrenia. Although another genetic variation (rs1186922) showed a weak association with schizophrenia (uncorrected p value for alleles = 0.038), the significance did not survive after Bonferroni correction. This study thus fails to support an association of genetic variations in the ENTH gene and schizophrenia. (c) 2006 Elsevier B.V. All rights reserved.
    关键词: Psychiatry
    日期: 2006-06
    關聯: Schizophrenia Research. 2006 Jun;84(2-3):236-243.
    Link to: http://dx.doi.org/10.1016/j.schres.2006.02.021
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0920-9964&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000238160500007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33646531215
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