國家衛生研究院 NHRI:Item 3990099045/14456
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    题名: CA10 is associated with HBV-related hepatocarcinogenesis
    作者: Chung, KM;Chen, YT;Hong, CC;Chang, IC;Lin, SY;Liang, LY;Chen, YR;Yeh, CT;Huang, SF
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Hepatocellular carcinoma (HCC) is the main threat for the patients infected with hepatitis B virus (HBV), but the oncogenic mechanism of HBV-related HCC is still controversial. Previously, we have found that several HBV surface gene (HBS) non-sense mutations are oncogenic. Among these mutations, sW182* was found to have the most potent oncogenicity. In this study, we found that Carbonic Anhydrase X (CA10) level was specifically increased in sW182* mutant-expressing cells. CA10 overexpression was also associated with HBS nonsense mutation in HBV-related HCC tumor tissues. Transformation and tumorigenesis assays revealed that CA10 had significant oncogenic activity. In addition, CA10 overexpression resulted in dysregulation of apoptosis-related proteins, including Mcl-1, Bcl-2, Bcl-xL and Bad. While searching for the regulatory mechanism of CA10, miR-27b was found to downregulate CA10 expression by regulating its mRNA degradation and its expression was decreased in sW182* mutant cells. Moreover, CA10 overexpression was associated with down-regulation of miR-27b in human HBV-related HCC tumor tissues with sW182* mutation. Therefore, induction of the expression of CA10 through repression of miR-27b by sW182* might be one mechanism involved in HBS mutation-related hepatocarcinogenesis.
    日期: 2022-09
    關聯: Biochemistry and Biophysics Reports. 2022 Sep;31:Article number 101303.
    Link to: http://dx.doi.org/10.1016/j.bbrep.2022.101303
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85133204435
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