國家衛生研究院 NHRI:Item 3990099045/1449
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    题名: Detection and quantification of aripiprazole and its metabolite, dehydroaripiprazole, by gas chromatography-mass spectrometry in blood samples of psychiatric patients
    作者: Huang, HC;Liu, CH;Lan, TH;Hu, TM;Chiu, HJ;Wu, YC;Tseng, YL
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Aripiprazole is a novel antipsychotic drug for the treatment of schizophrenia and schizoaffective disorders. In this study, a new method using gas chromatography-mass spectrometry (GC-MS) was developed and validated for the detection of aripiprazole and its main metabolite, dehydroaripiprazole, in plasma. Blood samples from seven psychiatric patients treated with aripiprazole (10-20 mg/day) underwent a solid-phase extraction (SPE) and N-methyl-N-trimethylsilytrifluoroacetamide (MSTFA) derivatization. The characteristic ions of mass spectra for aripiprazole and dehydroaripiprazole were ink 306, 292, 218 and 304, 290, 218, respectively. Extraction recoveries from this method were 75.4% (n = 5) for aripiprazole and 102.3 % (n = 5) for dehydroaripiprazole. The calibration curves of aripiprazole and dehydroaripiprazole were linear from 16 to 500 ng/ml (r(2) = 0.999) and 8 to 250 ng/ml (r(2) = 0.999), respectively. The respective limits of quantification (LOQs) for aripiprazole and dehydroaripiprazole evaluated in 0.5 ml of serum were 14.4 ng/ml and 6.9 ng/ml. Intra-assay and interassay precision and accuracy were within acceptable ranges. In this study, we also found that the mean trough concentrations in plasma at steady-state were 128.9 mu g/l for aripiprazole and 30.1 mu g/l for dehydroaripiprazole. (C) 2007 Elsevier B.V. All rights reserved.
    关键词: Biochemical Research Methods;Chemistry, Analytical
    日期: 2007-09-01
    關聯: Journal of Chromatography B. 2007 Sep;856(1-2):57-61.
    Link to: http://dx.doi.org/10.1016/j.jchromb.2007.05.026
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1570-0232&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000249615100009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34548140086
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