國家衛生研究院 NHRI:Item 3990099045/14548
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    题名: Metformin and the risk of chronic urticaria in patients with type 2 diabetes
    作者: Yen, FS;Hsu, CC;Hu, KC;Hung, YT;Hsu, CY;Wei, JC;Hwu, CM
    贡献者: Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research
    摘要: We conducted this study to determine the effect of metformin use on the risk of new-onset chronic urticaria in patients with type 2 diabetes (T2D). In total, 24,987 pairs of metformin users and nonusers were identified with propensity score-matching from Taiwan's National Health Insurance Research Database from 1 January 2000, to 31 December 2017. Multivariable Cox proportional hazards models were used to compare the risks of chronic urticaria development, severe chronic urticaria, and hospitalization for chronic urticaria between metformin users and nonusers. Compared with metformin nonuse, the aHRs (95% CI) for metformin use in chronic urticaria development, severe chronic urticaria, and hospitalization for chronic urticaria were 1.56 (1.39-1.74), 0.40 (0.12-1.30), and 1.45 (0.82-2.56), respectively. The cumulative incidence of chronic urticaria development was significantly higher in metformin users than in nonusers (p < 0.0001). A longer average cumulative duration of metformin use was associated with higher risks of new-onset and hospitalization for chronic urticaria than metformin nonuse. This nationwide cohort study showed that metformin use was associated with a significantly higher risk of chronic urticaria development. A longer average cumulative duration of metformin use was associated with a higher risk of outcomes. More prospective studies are needed to verify our results.
    日期: 2022-09-03
    關聯: International Journal of Environmental Research and Public Health. 2022 Sep 3;19(17):Article number 11045.
    Link to: http://dx.doi.org/10.3390/ijerph191711045
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000851913100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85137547031
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