國家衛生研究院 NHRI:Item 3990099045/14565
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    题名: Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control
    作者: Huang, PH;Yang, TY;Yeh, CW;Huang, SM;Chang, HC;Hung, YF;Chu, WC;Cho, KH;Lu, TP;Kuo, PH;Lee, LJ;Kuo, LW;Lien, CC;Cheng, HJ
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Mood disorders are an important public health issue and recent advances in genomic studies have indicated that molecules involved in neurodevelopment are causally related to mood disorders. BLM-s (BCL-2-like molecule, small transcript isoform), a BH3-only proapoptotic BCL-2 family member, mediates apoptosis of postmitotic immature neurons during embryonic cortical development, but its role in the adult brain is unknown. To better understand the physiological role of Blm-s gene in vivo, we generated a Blm-s-knockout (Blm-s(-/-)) mouse. The Blm-s(-/-) mice breed normally and exhibit grossly normal development. However, global depletion of Blm-s is highly associated with depression- and anxiety-related behaviors in adult mutant mice with intact learning and memory capacity. Functional magnetic resonance imaging of adult Blm-s(-/-) mice reveals reduced connectivity mainly in the ventral dentate gyrus (vDG) of the hippocampus with no alteration in the dorsal DG connectivity and in total hippocampal volume. At the cellular level, BLM-s is expressed in DG granule cells (GCs), and Blm-s(-/-) mice show reduced dendritic complexity and decreased spine density in mature GCs. Electrophysiology study uncovers that mature vGCs in adult Blm-s(-/-) DG are intrinsically more excitable. Interestingly, certain genetic variants of the human Blm homologue gene (VPS50) are significantly associated with depression traits from publicly resourced UK Biobank data. Taken together, BLM-s is required for the hippocampal mood control function. Loss of BLM-s causes abnormality in the electrophysiology and morphology of GCs and a disrupted vDG neural network, which could underlie Blm-s-null-associated anxiety and depression.
    日期: 2022-09-26
    關聯: Translational Psychiatry. 2022 Sep 26;12:Article number 411.
    Link to: http://dx.doi.org/10.1038/s41398-022-02184-6
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2158-3188&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000859861500001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85138633450
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