國家衛生研究院 NHRI:Item 3990099045/14567
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    題名: Industrialization’s eye view on theranostic nanomedicine
    作者: Sivasubramanian, M;Lin, LJ;Wang, YC;Yang, CS;Lo, LW
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: The emergence of nanomedicines (NMs) in the healthcare industry will bring about groundbreaking improvements to the current therapeutic and diagnostic scenario. However, only a few NMs have been developed into clinical applications due to a lack of regulatory experience with them. In this article, we introduce the types of NM that have the potential for clinical translation, including theranostics, multistep NMs, multitherapy NMs, and nanoclusters. We then present the clinical translational challenges associated with NM from the pharmaceutical industry’s perspective, such as NMs’ intrinsic physiochemical properties, safety, scale-up, lack of regulatory experience and standard characterization methods, and cost-effectiveness compared with their traditional counterparts. Overall, NMs face a difficult task to overcome these challenges for their transition from bench to clinical use.
    日期: 2022-08-19
    關聯: Frontiers in Chemistry. 2022 Aug 19;10:Article number 918715.
    Link to: http://dx.doi.org/10.3389/fchem.2022.918715
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2296-2646&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000858779100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85137204584
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