國家衛生研究院 NHRI:Item 3990099045/14590
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    题名: Gamma frequency inhibits the secretion and aggregation of amyloid-beta and decreases the phosphorylation of mTOR and Tau proteins in vitro
    其它题名: Gamma frequency inhibits the secretion and aggregation of amyloid-β and Decreases the Phosphorylation of mTOR and Tau Proteins in vitro
    作者: Yang, YH;Hsieh, SW;Chang, HW;Sung, JL;Chuu, CP;Yen, CW;Hour, TC
    贡献者: Institute of Cellular and Systems Medicine
    摘要: BACKGROUND: Alzheimer's disease (AD) was the main cause of dementia in an aging society; unfortunately, there is no effective treatment for AD now. Meditation has been reported to thicken the cerebral cortex, and gamma wave at a frequency of 40 hertz (Hz) was recorded during the meditation process from the brain. Previous study showed that non-invasive scintillation gamma frequency oscillation increased the space in recognition and memory of auditory cortex hippocampal gyrus in AD mice model. However, the AD-related molecular change by exposure of 40 Hz gamma frequency in brain cells was still unclear. OBJECTIVE: We investigated the AD-related molecular change by exposure of 40 Hz gamma frequency in SH-SY5Y cells. METHODS: We designed the light and sound generators at 40 Hz gamma frequency for this study. SH-SY5Y cells were exposed to sound or light of 40 Hz gamma frequency, respectively. The concentrations of amyloid-β40 (Aβ40) and amyloid-β42 (Aβ42) were quantified by enzyme-linked immunosorbent assay. The protein levels were examined by western blotting. The aggregation of Aβ42 was examined by thioflavin T assay. RESULTS: Our results showed that the secretion of Aβ, phosphorylation of AKT, mTOR, and tau, and aggregation of Aβ42 were significantly inhibited by 40 Hz gamma frequency in SH-SY5Y cells. The phosphorylation of 4E-BP1, downstream of mTOR, was induced by 40 Hz gamma frequency in SH-SY5Y cells. CONCLUSION: Our study showed 40 Hz gamma frequency involved in the inhibition of secretion and aggregation of Aβ and inhibition of p-Tau protein expression through the mTOR/4E-BP1/Tau signaling pathway.
    日期: 2022-11-08
    關聯: Journal of Alzheimer's Disease. 2022 Nov 8;90(2):917-928.
    Link to: http://dx.doi.org/10.3233/jad-220307
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1387-2877&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000886925300035
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85141938396
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