國家衛生研究院 NHRI:Item 3990099045/14623
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    题名: Transdermal delivery of succinate accelerates energy dissipation of brown adipocytes to reduce remote fat accumulation
    作者: Liao, FH;Yao, CN;Chen, SP;Wu, TH;Lin, SY
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Weight loss by increasing energy consumption of thermogenic adipocytes to overcome obesity remains a challenge. Herein, we established a transdermal device that was based on the local and temporarily controlled delivery of succinate (SC), a tricarboxylic acid cycle metabolic intermediate to stimulate the thermogenesis pathway of uncoupling protein 1 (UCP1) and accelerate energy dissipation of brown adipose tissue (BAT) under the dorsal interscapular skin, further initiating the consumption of fatty acids by systemic metabolism. SC microneedle patches significantly suppressed weight gain and fat accumulation of remote organs, including liver and peripheral white adipose tissue (WAT) in high-fat diet-induced obese mice. mRNA expression levels of Ucp1 in BAT and other browning markers in WAT were significantly elevated in the mice that were treated with SC microneedle. Thus, the energy dissipation of BAT using UCP1-mediated thermogenesis accelerated by the transdermal delivery of SC may become a potential and effective strategy for preventing obesity.
    日期: 2022-10-25
    關聯: Molecular Pharmaceutics. 2022 Oct 25;19(11):4299-4310.
    Link to: http://dx.doi.org/10.1021/acs.molpharmaceut.2c00628
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1543-8384&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000877380100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85140986251
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