國家衛生研究院 NHRI:Item 3990099045/14624
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    题名: A polysaccharide isolated from the herb bletilla striata combined with methylcellulose to form a hydrogel via self-assembly as a wound dressing
    作者: Jakfar, S;Lin, TC;Chen, ZY;Yang, IH;Gani, BA;Ningsih, DS;Kusuma, H;Chang, CT;Lin, FH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: The Bletilla striata Polysaccharide (BSP), a natural polysaccharide derived from the east Asian terrestrial orchid Bletilla striata, is an anti-inflammatory, antiviral, and antioxidant polysaccharide. Traditionally, it has been used to treat hemostasis and for wound healing. In this study, BSP was blended with methylcellulose (MC) and methylparaben (MP) to create a hydrogel through a self-assembly route as a wound dressing. The developed hydrogels were designed as M2Bx, M5Bx, and M8Bx. M stands for MC, and the number represents a percentage. Whereas the second letter of B stands for BSP, and x refers to the percentage variation of BSP: x = 0.5%, 1%, and 2%. All the developed MB hydrogels contained beta-glucopyranosyl and alpha-mannopyranosyl, and rheology test had a tan delta value >= 0.5. The pore sizes of the hydrogels decreased by increasing the MC and BSP content, and they had better properties with respect to water loss and their swelling ratio. Evaluations in vitro and in vivo showed that all of the developed MB hydrogels have good cell viability and wound-healing properties. The M8B2 hydrogel group was found to be superior to the others from within the developed MB hydrogels. Therefore, we believe that the M8B2 hydrogel formulation has a high potential for development as a wound dressing.
    日期: 2022-10-10
    關聯: International Journal of Molecular Sciences. 2022 Oct 10;23(19):Article number 1201.
    Link to: http://dx.doi.org/10.3390/ijms231912019
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000867796900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85139955774
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