國家衛生研究院 NHRI:Item 3990099045/14668

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14668

Title:	Air pollution during the perinatal period and neurodevelopment in children: A national population study in Taiwan
Authors:	Shih, P;Chiang, TL;Wu, CD;Shu, BC;Lung, FW;Guo, YL
Contributors:	National Institute of Environmental Health Sciences
Abstract:	Aim To evaluate the association between ambient particulate matter no larger than 2.5 mu m in diameter (PM2.5) during the prenatal and postnatal periods and infant neurodevelopmental parameters. Method We conducted a population-based birth cohort study using the Taiwan Birth Cohort Study. Participants were assessed for developmental conditions through home interviews at 6 months and 18 months of age. Exposure to PM2.5 of mothers and infants during perinatal periods was estimated using hybrid kriging/land-use regression. The exposure was linked to each participant by home address. Logistic regression was then conducted to determine the risk of neurodevelopmental delay in relation to PM2.5. Results A total of 17 683 term singletons without congenital malformations were included in the final analysis. PM2.5 during the second trimester was associated with increased risks of delays in gross motor neurodevelopmental milestones (adjusted odds ratio [aOR] 1.09 per 10 mu g/m(3) increase in exposure to PM2.5). Delayed fine motor development was also found to be related to exposure to PM2.5 in the second and third trimesters (aOR 1.06), as was personal-social skill (aOR 1.11 for the second trimester and 1.06 for the third). These neurodevelopmental parameters were unrelated to postnatal PM2.5 exposure. Interpretation Exposure to ambient PM2.5 during pregnancy was significantly related to delay in gross motor, fine motor, and personal-social development in this population-based study.
Date:	2023-06
Relation:	Developmental Medicine and Child Neurology. 2023 Jun;65(6):783-791.
Link to:	http://dx.doi.org/10.1111/dmcn.15430
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0012-1622&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000880025700001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85141578650
Appears in Collections:	[Yue-Liang Guo] Periodical Articles

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