國家衛生研究院 NHRI:Item 3990099045/14685
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14685


    Title: PD-L1 expression in high-risk early-stage colorectal cancer-its clinical and biological significance in immune microenvironment
    Authors: Chung, BS;Liao, IC;Lin, PC;Wu, SY;Kang, JW;Lin, BW;Chen, PC;Chan, RH;Lee, CT;Shen, MR;Chen, SH;Yeh, YM
    Contributors: National Institute of Cancer Research
    Abstract: Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that can regulate immune responses in the tumor microenvironment (TME); however, the clinical applications of PD-L1 in early-stage colorectal cancer (CRC) remain unclear. In this study, we aimed to investigate the relationship between PD-L1 expression and survival outcome and explore its relevant immune responses in CRC. PD-L1 expression was evaluated by immunohistochemical staining to determine the tumor proportion score and combined positive score (CPS) in a Taiwanese CRC cohort. The oncomine immune response research assay was conducted for immune gene expression analyses. CRC datasets from the TCGA database were reappraised for PD-L1-associated gene enrichment analyses using GSEA. The high expression of PD-L1 (CPS >= 5) was associated with longer recurrence-free survival (p = 0.031) and was an independent prognostic factor as revealed by multivariate analysis. High PD-L1 expression was related to six immune-related gene signatures, and CXCL9 is the most significant overexpressed gene in differential analyses. High CXCL9 expression correlated with increased infiltration levels of immune cells in the TME, including CD8+ T lymphocytes and M1 macrophages. These findings suggest that high PD-L1 expression is a prognostic factor of early-stage CRC, and CXCL9 may play a key role in regulating PD-L1 expression.
    Date: 2022-10-31
    Relation: International Journal of Molecular Sciences. 2022 Oct 31;23(21):Article number 13277.
    Link to: http://dx.doi.org/10.3390/ijms232113277
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000882729300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85141837269
    Appears in Collections:[Shang-Hung Chen] Periodical Articles

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