國家衛生研究院 NHRI:Item 3990099045/14727
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    题名: PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair
    作者: Ho, YC;Ku, CS;Tsai, SS;Shiu, JL;Jiang, YZ;Miriam, HE;Zhang, HW;Chen, YT;Chiu, WT;Chang, SB;Shen, CH;Myung, K;Chi, P;Liaw, H
    贡献者: National Institute of Cancer Research
    摘要: Replication fork reversal which restrains DNA replication progression is an important protective mechanism in response to replication stress. PARP1 is recruited to stalled forks to restrain DNA replication. However, PARP1 has no helicase activity, and the mechanism through which PARP1 participates in DNA replication restraint remains unclear. Here, we found novel protein-protein interactions between PARP1 and DNA translocases, including HLTF, SHPRH, ZRANB3, and SMARCAL1, with HLTF showing the strongest interaction among these DNA translocases. Although HLTF and SHPRH share structural and functional similarity, it remains unclear whether SHPRH contains DNA translocase activity. We further identified the ability of SHPRH to restrain DNA replication upon replication stress, indicating that SHPRH itself could be a DNA translocase or a helper to facilitate DNA translocation. Although hydroxyurea (HU) and MMS induce different types of replication stress, they both induce common DNA replication restraint mechanisms independent of intra-S phase activation. Our results suggest that the PARP1 facilitates DNA translocase recruitment to damaged forks, preventing fork collapse and facilitating DNA repair.
    日期: 2022-12
    關聯: PLoS Genetics. 2022 Dec;18(12):Article number e1010545.
    Link to: http://dx.doi.org/10.1371/journal.pgen.1010545
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1553-7404&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000924505200028
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85144635875
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