國家衛生研究院 NHRI:Item 3990099045/14761
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    题名: IFN-stimulated metabolite transporter ENT3 facilitates viral genome release
    作者: Hsieh, YT;Tsai, TL;Huang, SY;Heng, JW;Huang, YC;Tsai, PY;Tu, CC;Chao, TL;Tsai, YM;Chang, PC;Lee, CK;Yu, GY;Chang, SY;Dzhagalov, IL;Hsu, CL
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: An increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this study, we found that the expression of equilibrative nucleoside transporter 3 (ENT3, encoded by solute carrier family 29 member 3, Slc29a3) is part of the innate immune response, which is rapidly upregulated upon pathogen invasion. The transcription of Slc29a3 is directly regulated by type I interferon-induced signaling, demonstrating that this metabolite transporter is an interferon-stimulated gene (ISG). Suprisingly, we unveil that several viruses, including SARS-CoV-2, require ENT3 to facilitate their entry into the cytoplasm. The removal or suppression of Slc29a3 expression is sufficient to significantly decrease viral replication in vitro and in vivo. Our study reveals that ENT3 is a pro-viral ISG co-opted by some viruses to gain a survival advantage.
    日期: 2023-03-06
    關聯: EMBO Reports. 2023 Mar 6;24(3):Article number e55286.
    Link to: http://dx.doi.org/10.15252/embr.202255286
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1469-221X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000950202800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85146455320
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