國家衛生研究院 NHRI:Item 3990099045/14780
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14780


    Title: Splice-site variants in the gene encoding GABA-A receptor delta subunit are associated with amphetamine use in patients under methadone maintenance treatment
    Authors: Lin, YF;Chou, WH;Liu, TH;Fang, CP;Kuo, HW;Kuo, PH;Tsai, SJ;Wang, SC;Chung, RH;Tsou, HH;Chen, ACH;Liu, YL
    Contributors: Center for Neuropsychiatric Research;Institute of Population Health Sciences
    Abstract: Chronic opioid use disorder patients often also use other substances such as amphetamines. The gene-based analysis method was applied in the genomic database obtained from our previous study with 343 methadone maintenance treatment (MMT) patients. We found that the gene encoding gamma-aminobutyric acid type A receptors (GABA-A receptor) delta subunit isoforms (GABRD) was associated with amphetamine use in heroin dependent patients under MMT in Taiwan. A total of 15% of the 343 MMT patients tested positive for amphetamine in the urine toxicology test. Two genetic variants in the GABRD, rs2889475 and rs2376805, were found to be associated with the positive urine amphetamine test. They are located in the exon 1 of the splice variant and altered amino acid compositions (T126I, C/T, for rs2889475, and R252Q, G/A, for rs2376805). The CC genotype carriers of rs2889475 showed a four times higher risk of amphetamine use than those with TT genotype. The GG genotype carriers of rs2376805 showed a three times higher risk of amphetamine use than the AA genotype carriers. To our knowledge, this is the first report that demonstrated an association of the delta splice variant isoform in the GABA-A receptor with an increased risk of amphetamine use in MMT patients. Our results suggest that rs2889475 and rs2376805 may be indicators for the functional role and risk of amphetamine use in MMT patients.
    Date: 2023-01
    Relation: International Journal of Molecular Sciences. 2023 Jan;24(1):Article number 721.
    Link to: http://dx.doi.org/10.3390/ijms24010721
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000909997900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85145975436
    Appears in Collections:[Yu-Li Liu] Periodical Articles
    [Sheng-Chang Wang] Periodical Articles
    [Wen-Hai Chou] Periodical Articles
    [Yen-Feng Lin] Periodical Articles
    [Hsiao-Hui Sophie Tsou] Periodical Articles
    [Ren-Hua Chung] Periodical Articles

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