國家衛生研究院 NHRI:Item 3990099045/14801
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 910231      線上人數 : 824
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/14801


    題名: Investigation into the content of red material in EUS-guided pancreatic cancer biopsies
    作者: Lin, MY;Su, YY;Yu, YT;Huang, CJ;Sheu, BS;Chang, WL
    貢獻者: National Institute of Cancer Research
    摘要: BACKGROUND AND AIMS: The red material occupying the larger portion of the acquired sample in EUS fine needle biopsy (FNB) is seldom investigated. We aimed to evaluate the composition of the red material. METHODS: Patients with a solid pancreatic mass who received EUS FNB from Sep. 2020 to Jun. 2021 were enrolled. The white and red materials were separated immediately after puncture. Needle passes proceeded until two specimens with more than 4 mm of white material were obtained. An extra needle pass was conducted for DNA collection. The DNA amount, KRAS mutation type and mutation allele frequency were compared between the white and red material. RESULTS: A total of 40 patients were enrolled with 68 paired white and red materials. The diagnostic accuracy was slightly higher in the white material (92.5% vs. 82.5%, p=0.219). On the histology slides, the area of the tumor gland was comparable in both materials, but the total tissue area was larger in the red material (9.74 & 10.74 mm(2) larger by GLM &GEE, both p<0.001). The amount of DNA was significantly higher in the red material (2.99 μg [IQR 1.67-7.17] vs. 0.70 μg [IQR 0.30-1.19], p<0.001). Common pancreatic adenocarcinoma KRAS mutation was identified at a rate of 85% for the white material and 95% for the red material. Whether it was red or white material, there was a high concordance of KRAS mutation types (34/40, 85%) and high correlation of mutation allele frequency (ρ=0.66, p<0.001). CONCLUSIONS: In EUS FNB, the red material contains a higher amount of tumor DNA, and can be an alternative source for tumor DNA analysis.
    日期: 2023-06
    關聯: Gastrointestinal Endoscopy. 2023 Jun;97(6):1083-1091.e1.
    Link to: http://dx.doi.org/10.1016/j.gie.2023.01.041
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0016-5107&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000999195700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85152400782
    顯示於類別:[蘇勇曄] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB36720289.pdf43110KbAdobe PDF129檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋