國家衛生研究院 NHRI:Item 3990099045/14906
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    题名: The comprehensive effects of carassius auratus complex formula against lipid accumulation, hepatocarcinogenesis, and COVID-19 pathogenesis via stabilized G-Quadruplex and reduced cell senescence
    作者: Hsiao, HY;Hsu, PJ;Sampurna, BP;Lin, YJ;Lin, KH;Zhao, YN;Wang, HD;Yuh, CH
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Carassius auratus complex formula (CACF) is a traditional Chinese medicine known for its antidiabetic effects. Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide, and there are currently no effective therapies for advanced HCC. This study explores the comprehensive effects and possible mechanisms of CACF on HCC. The results show that CACF reduces the viability of hepatoma cells in vitro, while benefiting normal hepatocytes. In addition, CACF inhibits hepatoma cell growth in a zebrafish xenotransplantation model and decreases lipid accumulation, represses inflammation and cell proliferation markers in fatty acid translocase (CD36) transgenic zebrafish, and inhibits the expression of cell proliferation and β-catenin downstream targets in telomerase (tert) transgenic zebrafish models. Ingenuity Pathway Analysis reveals that CACF exerts multiple functions, including reduction of inflammation and inhibition of lipid transporter and PPAR signaling pathway. Surprisingly, CACF also regulates the expression of genes and reduces coronavirus infection and pathogenesis in a zebrafish model. CACF treatment is validated to regulate the expression of genes for anti-coronavirus activity. Mechanistically, CACF stabilizes G-quadruplex and reduces cell senescence associated β-galactosidase activity. In summary, CACF may be a promising therapeutic agent with multiple functions including anticancer, anti-inflammation, and anti-microorganisms in a zebrafish model.
    日期: 2023-07
    關聯: Advanced Biology. 2023 Jul;7(7):Article number e2200310.
    Link to: http://dx.doi.org/10.1002/adbi.202200310
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000955152100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85150932421
    显示于类别:[喻秋華] 期刊論文

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